Thyroid dyshormonogenesis is a leading cause of congenital hypothyroidism, a highly prevalent but treatable condition.Thyroid hormone (TH) synthesis is dependent on the formation of reactive oxygen species (ROS).In humans, the primary sources for ROS production during thyroid hormone synthesis are the NADPH oxidases DUOX1 and DUOX2.Indeed, mutation
Exact sequence matches in genomic studies
The purpose Silhouettes of this article is to review usage of exact sequence matches in different field of genomic studies.Methods.The presentation is built in the form of a brief review of clearly non-exhaustive list of works in which the authors inferred biological knowledge using statistical properties of exact matches between different genomic
A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx.
BACKGROUND: Some low molecular weight heparins (LMWHs) prolong survival of cancer patients and inhibit experimental metastasis.The underlying mechanisms are still not clear but it has been suggested that LMWHs (at least in part) limit metastasis by preventing cancer cell-induced destruction of the endothelial glycocalyx.METHODOLOGY/PRINCIPAL FINDIN